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Scientists of the Pavlov Institute of Physiology of the Russian Academy of Sciences and the Institute of Experimental Medicine have shown the effectiveness of using autoprobiotic bifidobacteria to normalize the intestinal microbiota in a state of dysbiosis.

The widespread use of probiotics (beneficial bacteria that are usually part of the human and animal microbiota) in medical practice in recent decades has shown their effectiveness in the treatment of dysbiosis of various origins caused by diseases or the use of antimicrobial drugs. However, many probiotics are quickly eliminated from the body for a number of reasons, often without reaching the concentration at which their positive effects manifest themselves.

Therefore, at present, the attention of physicians and biologists is directed to studying the beneficial effects of their own, autoprobiotic strains of bacteria that are representatives of their own microflora, to which the body has an immunological tolerance, and there is no antagonistic activity on the part of its own microbiota.

A model of experimental dysbiosis (changes in the composition of microflora) in rats was developed by scientists from the Institute of Experimental Medicine (IEM) under the guidance of Professor, Doctor of Biological Sciences Elena Igorevna Ermolenko in order to preclinically determine the effectiveness of various antimicrobial drugs in relation to the normalization of the intestinal microbiota.

However, prior to joint research with the Pavlov Institute of Physiology of the Russian Academy of Sciences (IF RAS), using this model, the effect of antimicrobial drugs on intestinal digestive enzymes, including those that are also involved in protection against antigens and in the regulation of some other important physiological functions, was practically not analyzed.

"In our study, using the model of experimental dysbiosis in rats, it was shown that autoprobiotic bifidobacteria are effective not only in restoring the intestinal microbiota, but also in normalizing the activity of key intestinal digestive enzymes, including those that are also involved in protecting against antigens and regulating immune responses," comments the study author, head of the Laboratory of Nutrition Physiology Lyudmila Viktorovna Gromova.

However, in the course of our study, a negative effect was also found associated with the inhibition of motor activity of the colon under the influence of these autoprobiotic bifidobacteria. This suggests that the use of autoprobiotic bacteria, apparently, should be carried out in combination with other autoprobiotics, which will prevent the manifestation of this effect. However, in some cases, for example, in the presence of diarrhea, such a negative effect may be useful.

"To date, only the first steps have been taken towards studying the beneficial effects of two autoprobiotics (autoprobiotic enterococci and bifidobacteria), so it is premature to make predictions about the feasibility of using these drugs in the treatment of specific diseases accompanied by dysbiosis," Gromova emphasizes the importance of continuing experiments.

The article is published in the National Library of Medicine

Photo-Intestinal bacteria © Bowenworksinlondon
Source: naked-science.ru, sci-dig.ru