SCIENTIFIC EDUCATIONAL CENTER science idea

Wound healing is a complex, multi–stage process that can be accompanied by complications. Despite the abundance of wound treatment methods and a variety of dressings, the development of safe and effective materials for regenerative medicine that do not require replacement during the entire healing period remains an urgent task for researchers. Fibrous materials based on biodegradable polymers and modifying additives are considered promising in this field. Researchers under the jurisdiction of the Ministry of Education and Science of the Russian Federation of the N.M. Emanuel IBHF of the Russian Academy of Sciences and the G.V. PRUE. Plekhanova together with colleagues from Lomonosov Moscow State University have developed and tested new biocompatible nonwovens with high antibacterial properties.

In the course of joint research, employees of the Laboratory of Physico-Chemistry of Synthetic and Natural Polymer Compositions of the IBCF RAS, the Basic Department of Chemistry of Innovative Materials and Technologies of Plekhanov Russian University of Economics and the Polymer Structure Research Laboratory of the Department of High-Molecular Compounds of Lomonosov Moscow State University received durable and effective composites that will help in the future to create "breathable" materials for disinfection of wounds and their accelerated healing.

"We have successfully completed the first stage of work on the creation of new materials for regenerative medicine with unique properties, having received a line of materials with controlled morphology and high stability to environmental conditions. Studies of the biocompatibility of materials in vitro (in vitro) have already been certified, and we are starting to prepare for in vivo studies (inside a living organism)," said Polina Tyubaeva, a leading researcher at the Basic Department of Chemistry of Innovative Materials and Technologies of Plekhanov Russian University of Economics. Scientists have already created antimicrobial dressings from the obtained material, the components of which are able to stop bleeding, as well as Achilles tendon implants.

Among the important distinguishing characteristics of composites, researchers note high porosity, good mechanical and antibacterial properties, as well as a controlled rate of biodegradation. "The main advantage of our materials is that they will find application in personalized medicine, and will also allow creating universal wound healing materials due to the ability to effectively regulate the structural features of the material and, as a result, its most important properties," explained Polina Tyubaeva, co-author of the study.

The research team created composites based on semi-crystalline biodegradable poly-3-hydroxybutyrate and natural iron-containing porphyrin gemin. The scientists were able to show the influence of the structure on the resistance of fibrous materials to environmental conditions, as well as describe the possibilities of directed modification of semi-crystalline polymers to increase their valuable properties in operation. Since polymers and modifying additives are of natural origin and have a high level of biocompatibility, their use opens up broad prospects for the creation of environmentally friendly wound healing materials. Such materials have a number of advantages over analogues existing on the market, which are due to the possibility of directed modification of the non-woven layer and the manufacture of a wide range of wound healing agents with controlled porosity, an additional insulating self-absorbing layer. Also, in such composites, there is a gradual release of anesthetics, antibiotics and other drugs, depending on the type of wound and the area of damage. The results of the study were published in one of the leading scientific journals, the scientific project was supported by the Russian Science Foundation.

PHOTO: co-author of the study Polina Tyubaeva, Leading researcher of the Basic Department of Chemistry of Innovative Materials and Technologies of Plekhanov Russian University of Economics

Information and photos provided by the press service of the Ministry of Education and Science of Russia

Posted by Irina Usyk Information taken from the portal "Scientific Russia" (https://scientificrussia.ru/)