SCIENTIFIC EDUCATIONAL CENTER science idea

The human body is a complex system of a large number of cells that coordinate their vital activity within a single system. After receiving various deep, open injuries, a person may lack areas of such a vital organ as the skin. Scientists of Perm Polytechnic University have developed a mathematical model that is designed for growing skin. Specialists from the field of tissue engineering will be able to use the developed technology to select the most effective epithelial repair plan, taking into account the individual characteristics of the structure of the cells of the human body.

— The mathematical model developed by us solves problems in the development of scaffolds. Scaffolds are temporary "scaffolds" for tissue repair, which then dissolve. For example, a complex fracture has occurred, which may not grow properly or not recover at all. They turn to specialists in the field of tissue engineering with such a problem. These specialists prepare a scaffold using 3D printing from a biodegradable material. Then the system is filled with bone tissue cells and placed in a nutrient medium, where the cells begin to grow intensively along the "frameworks". It is worth noting that this system is being developed in the likeness of a broken section. In this way, bone tissue is grown and implanted into the fracture site, — adds Ivan Krasnyakov, head of the Laboratory of the Department of Applied Physics of PNRPU.

According to scientists, the model includes two important processes that mimic the properties of real cells: mitotic division and intercalation of cells.

— The research was carried out using standard methods of mathematical modeling and numerical experiments. A discrete model of a deformable cell is taken as a basis. An equation of motion based on elastic potential energy is written for each vertex of the cell. As the tissue evolves, it tends to occupy a position corresponding to the minimum of potential energy," says Dmitry Bratsun, Doctor of Physical and Mathematical Sciences, Head of the Department of Applied Physics at PNRPU.

According to scientists, this matmodel is universal and can be easily adapted to solve other problems. Thus, polytechnics have already carried out a number of studies on the development of carcinoma (epithelial cancer). The technology can be useful for specialists in the field of tissue engineering, as well as for theoretical researchers.

The article was published in the journal Interfacial Phenomenon and Heat Transfer
The information is taken from the portal "Scientific Russia" (https://scientificrussia.ru/)

PHOTO: Micrograph of healthy tissue of single-layer flat epithelium © PNRPU Press Service

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